My research involves applying mathematical and computational techniques to biological problems.
My PhD is funded by the British Heart Foundation, as part of a CoMPLEX MRes/MPhil studentship.
PhD Project: Modelling the Impact of Cell Seeding Strategies on Cell Survival and Vascularisation in Engineered Tissue
Nerve constructs are used to aid the regeneration of neurons after
peripheral nerve injury. The project involves the development of a mathematical
framework to model cell survival and vacularisation within nerve constructs, which
will be capable of directing and accelerating the design of constructs in the future.
Experimental data has been used to parameterise the model.
Supervisors: Dr. James Phillips (Biomaterials and Tissue Engineering, UCL)
& Dr. Rebecca Shipley (Mechanical Engineering, UCL)
I have used the finite element software COMSOL to parameterise a mathematical model of cell-oxygen-VEGF interactions using in vitro data. I am now running simulations in a cylindrical geometry representing a nerve construct, to make predictions about the best way of seeding cells within engineered tissue to facilite cell survival and vascular growth.
MRes Summer and Mini Project pdfs are available upon request.
MRes Summer Project: Predicting the rupture
risk of brain aneurysms using computational approaches: a HemeLB validation study
An investigation into the impact of different factors upon cerebral
blood flow simulation results, through the use of patient specific data
and the simulation environment HemeLB. Simulations were run using the national
supercomputer ARCHER. The work helped to identify sources of error, which
could have implications for the clinical use of such simulations to quantify
the risk of brain aneurysm rupture.
Supervisors: Prof. Peter Coveney, Dr. Derek Groen & Dr. Hoskote Chandrashekar
Rachel Coy © 2015-2019 | UCL CoMPLEX
MRes Mini Projects:
Modelling the impact of vessel
stiffening upon arteriolar networks
Investigating the mechanisms behind microvascular rarefaction.
Supervisors: Prof. Alun Hughes & Dr. Ryo Torii
A mathematical model to investigate angiogenesis
in nerve repair conduits
Modelling the relationship
over time between the distributions of oxygen concentration, cell population density
and VEGF concentration along a nerve repair conduit.
Supervisors: Dr. James Phillips & Dr. Rebecca Shipley
A study of the relationship between ectopic beat frequency and heart rate variability in ARVC patients
Investigating whether there are correlations between heart rate
variability parameters, which reflect sympathetic and parasympathetic modulation
of the heart rate, and ectopic beat frequency in ARVC patients.
Supervisors: Dr. Ben Hanson & Dr. Pier Lambiase